ICurcumin iboniswe ukuthuthukisa amaSerum Inflammatory Markers

Imiphumela yocwaningo olusha olushicilelwe ephephabhukwini i-Biomed Central BMC ikhombise ukukhishwa kwe-turmeric bekusebenza njenge-paracetamol ekwehliseni ubuhlungu nezinye izimpawu ze-knee osteoarthritis (OA). Ucwaningo lukhombisile ukuthi i-compound ayitholakali yayisebenza kangcono ekunciphiseni ukuvuvukala.

I-Osteoarthritis yisifo esiwohlozayo samalunga we-articular abonakala ngokuwohloka koqwanga, ulwelwesi oluhlangene, imisipha kanye nethambo elingaphansi. Ukubonakaliswa okuvamile kwe-osteoarthritis ukuqina nobuhlungu.

Iholwa nguShuba Singhal, PhD, lolu cwaningo lomtholampilo olwenziwa ngokungahleliwe lwenziwa eMnyangweni Wezithambo waseLok Nayak Jai Prakash Hospital / Maulana Azad Medical College, eNew Delhi. Ocwaningweni, iziguli ezingama-193 ezitholwe zine-osteoarthritis yamadolo zazihlelwe ngokungahleliwe ukuthola i-turmeric extract (BCM-95) njenge-capsule engu-500 mg kabili ngosuku, noma ithebhulethi engu-650 mg yeparacetamol kathathu nsuku zonke amasonto ayisithupha.

Izimpawu zesifo samathambo emadolweni sobuhlungu, ukuqina okuhlangene, nokuncipha kokusebenza komzimba kwahlolwa kusetshenziswa iWestern Ontario neMcMaster Universities Osteoarthritis Index (WOMAC). Ngemuva kwamasonto ayisithupha okwelashwa, ukuhlaziywa komphenduli kukhombise ukuthuthuka okuphezulu kuzikolo ze-WOMAC kuwo wonke amapharamitha afaniswa neqembu le-paracetamol, ne-18% yeqembu le-BCM-95 elibika ukuthuthuka okungu-50%, kanye ne-3% yezifundo ezibona ukuthuthuka okungu-70%.

Le miphumela ikhonjiswe kahle kumaka wokuvuvukala we-serum eqenjini le-BCM-95: amazinga e-CRP ancishiswe ngama-37.21%, futhi amazinga e-TNF-α asikwa ngo-74.81%, okukhombisa ukuthi i-BCM-95 yenze kangcono kune-paracetamol.

Ucwaningo belulandela ucwaningo lwe-Arjuna olwenziwe esikhathini esingaphezu konyaka esedlule olukhombise ukuxhumana okuhle phakathi kokwakhiwa kwe-curcumin yayo eyinhloko kanye nokunakekelwa kwe-osteoarthritic.

"Inhloso yocwaningo lwamanje kwakungokwakhela phezu kwezifundo zangaphambilini ukunikeza ukucaciseka okungcono kanye nokucaciswa ngokufaka omaka abaningi kanye nendlela engcono yokushaya amagoli," kusho uBenny Antony, umqondisi ophethe ngokuhlanganyela we-Arjuna. "Umphumela we-anti-arthritic we-BCM-95 ku-osteoarthritis ubangelwa amandla ayo wokulinganisa izimpawu zokulwa nokuvuvukala i-TNF ne-CRP."

Idolo OA liyimbangela ehamba phambili yokukhubazeka nobuhlungu phakathi kwabantu abadala nabadala. Kulinganiselwa ukuthi u-10 kuya ku-15% wabo bonke abantu abadala abaneminyaka engaphezu kwengama-60 banezinga elithile le-OA, ngokwanda kwabantu besifazane kunabesilisa.

"Lolu cwaningo luqinisekisa kabusha umphumela wokulwa nesifo samathambo we-BCM-95 futhi lunikeza ithemba elivuselelwe ngezigidi ukwenza ngcono impilo yazo," kusho uNipen Lavingia, umeluleki wemikhiqizo emisha ye-Arjuna Natural ezinze eDallas, TX.

“Sifunda kabanzi ngezindlela ezisebenza nomphumela wokulwa nokuvuvukala we-curcumin esikholelwa ukuthi ungumphumela wokukwazi kwawo ukuvimbela amasignali ahlasela ukuvuvukala, njenge-prostaglandins, i-leukotrienes, ne-cyclooxygenase-2. Ngaphezu kwalokho, i-curcumin ikhonjisiwe ukuthi icindezela ama-cytokines amaningi kanye nabalamuli bokukhishwa kwabo, njenge-tumor necrosis factor-α (TNF-α), IL-1, IL-8, ne-nitric oxide synthase, ”kusho u-Antony.

Ukuhlanganiswa okuyingqayizivele kwe-BCM-95 kwama-curcuminoids nezakhi ze-turmerone ezicebile ezibalulekile kunqoba izithiyo ze-curcumin zesici sokutholakala ngenxa yemvelo ephezulu ye-lipophilic.


Isikhathi Iposi: Apr-12-2021