Imiphumela yocwaningo olusha olushicilelwe kumagazini i-Biomed Central BMC ibonise ukuthi i-turmeric extract iphumelele njenge-paracetamol ekunciphiseni ubuhlungu nezinye izimpawu ze-knee osteoarthritis (OA). Ucwaningo lubonise ukuthi i-bioavailable compound iphumelele kakhulu ekwehliseni ukuvuvukala.
I-osteoarthritis yisifo esiwohlokayo samalunga e-articular esibonakala ngokuwohloka kwe-cartilage, ulwelwesi oluhlangene, imigqa, kanye nethambo elingaphansi. Ukubonakaliswa okuvamile kwe-osteoarthritis ukuqina nobuhlungu.
Iholwa ngu-Shuba Singhal, PhD, lolu cwaningo lomtholampilo olungahleliwe, olulawulwayo lwenziwa eMnyangweni Wezamathambo we-Lok Nayak Jai Prakash Hospital/Maulana Azad Medical College, eNew Delhi. Ocwaningweni, iziguli ze-193 ezitholwe zine-osteoarthritis yamadolo zahlelwa ngokungahleliwe ukuze zithole i-turmeric extract (BCM-95) njenge-capsule engu-500 mg izikhathi ezimbili ngosuku, noma ithebhulethi engu-650 mg ye-paracetamol kathathu nsuku zonke amasonto ayisithupha.
Izimpawu zesifo samathambo edolo zobuhlungu, ukuqina kwamalunga, nokuncipha kokusebenza komzimba kwahlolwa kusetshenziswa iWestern Ontario kanye neMcMaster Universities Osteoarthritis Index (WOMAC). Ngemva kwamasonto ayisithupha okwelashwa, ukuhlaziya kwabaphenduli kubonise ukuthuthuka okuphawulekayo kuzikolo ze-WOMAC kuwo wonke amapharamitha afana neqembu le-paracetamol, kwathi u-18% weqembu le-BCM-95 libika ukuthuthukiswa okungama-50%, kanye no-3% wezifundo eziphawula ukuthuthukiswa okungama-70%.
Le miphumela iboniswe kahle kumakaki okuvuvukala kwe-serum yeqembu le-BCM-95: Amazinga e-CRP ancishiswa ngo-37.21%, futhi amazinga e-TNF-α ancishiswa ngo-74.81%, okubonisa ukuthi i-BCM-95 yenza kangcono kune-paracetamol.
Ucwaningo lwalulandela ucwaningo lwe-Arjuna olwenziwa ngaphezu konyaka odlule olwabonisa ukuxhumana okuhle phakathi kokwakhiwa kwe-curcumin ye-flagship kanye nokunakekelwa kwe-osteoarthritic.
"Inhloso yocwaningo lwamanje kwakuwukwakha phezu kwezifundo zangaphambili ukunikeza ukucaca okungcono nokucacisa ngokufaka amamaki amaningi kanye nendlela engcono yokufaka amaphuzu," kusho u-Benny Antony, umqondisi ophethe ohlangene we-Arjuna. "Umphumela we-anti-arthritic we-BCM-95 ku-osteoarthritis ubangelwa amandla ayo okulinganisa izimpawu zokulwa nokuvuvukala i-TNF ne-CRP."
I-Knee OA iyimbangela ehamba phambili yokukhubazeka nobuhlungu phakathi kwabantu abadala nabadala. Ilinganiselwa ku-10 kuya ku-15% wabo bonke abantu abadala abadala kuneminyaka engama-60 banezinga elithile le-OA, okuvame kakhulu phakathi kwabesifazane kunabesilisa.
"Lolu cwaningo luqinisekisa kabusha umphumela wokulwa nesifo samathambo we-BCM-95 futhi lunikeza ithemba elivuselelwe ngezigidi ukuze zithuthukise izinga lempilo yazo," kusho u-Nipen Lavingia, umeluleki wokusungula umkhiqizo we-Arjuna Natural ozinze eDallas, TX.
“Sifunda kabanzi mayelana nezinqubo ezingemuva komphumela wokulwa nokuvuvukala kwe-curcumin esikholelwa ukuthi uwumphumela wekhono layo lokuvimbela amasiginali okuvuvukala, njenge-prostaglandin, i-leukotrienes, ne-cyclooxygenase-2. Ngaphezu kwalokho, i-curcumin iye yaboniswa ukucindezela ama-cytokines amaningana ane-pro-inflammatory kanye nabalamuleli bokukhululwa kwawo, njenge-tumor necrosis factor-α (TNF-α), i-IL-1, i-IL-8, ne-nitric oxide synthase, "kusho u-Antony.
Inhlanganisela eyingqayizivele ye-BCM-95 ye-curcuminoids kanye nezingxenye zikawoyela obalulekile ezicebile nge-turmerone zinqoba izithiyo zesici se-curcumin ze-bioavailability ngenxa yemvelo yayo ephezulu ye-lipophilic.
Isikhathi sokuthumela: Apr-12-2021